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This highly variable, complex region contained many SVs, making it difficult to phase against the reference genome, but allowed full resolution through the de novo approach.
It becomes more and more difficult to phase separate with generation number increasing from 1 to 5 due to the architectural complexity.
As a natural consequence of their experimental design, many of these surveys tend to sequence redundant haplotype segments due to their high frequency in the base population, and the variants discovered within sequencing data are difficult to phase.
For this reason, in contrast to wage subsidies which can prove difficult to phase out72 and are subject to strong locking-in effects, subsidizing hirings have lower locking-in effects73.
The phasing of the sequence data may also have a higher number of switch errors per centimorgan because low-frequency variants are generally more difficult to phase than high-frequency variants.
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Thirdly, although the NfG stipulate that drugs with only phase II studies must undergo further trials, it is difficult to arrange phase III trials when the efficacy of an authorised drug is considered well established.
This longer time scale makes it more difficult to maintain phase stability needed for Doppler OCT while particles traverse the imaging beam.
Our efficacy results compare well with the other combination regimen in pancreatic cancer although it is difficult to compare phase II studies.
Because these stations are approximately located at the opposite direction of faulting, the rupture directivity reduces significantly the observed amplitude of Rayleigh wave to make it difficult to measure phase-velocity due to the problem of phase-skip, especially for the short-period surface waves.
It is difficult to discriminate phases of tremor for assigning wave types to the estimated apparent slowness.
Fourth, due to the non-perfect synchronization between the wavelength sweep and data acquisitions, the phase stability of SS-OCT system is relatively poor compared to that of the SD-OCT system, making it difficult to utilize phase-sensitive functional imaging approaches to image blood flows.
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