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However, muscovite mica is not further processable, making it difficult to pattern device architecture directly on the growth substrate.
Although e-beam lithography is the most commonly used technique in constructing nanostructures with high degree of control, the generation of secondary electrons during electron bombardment makes it difficult to pattern with sub-10-nm resolution.
The surfaces of graphite electrodes are non-uniform and difficult to pattern in small-scale devices.
This extends template stripping to high-melting-point solids, such as W, and transparent conductors, such as ITO, both of which are difficult to pattern with conventional methods.
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In general, it is difficult to form oxide patterns on SiC using AFM-LO because of both physical hardness and chemical inactivity.
However, the abstract and informal nature of prevailing pattern descriptions makes it difficult to use design patterns.
In particular, collagen is a difficult protein to pattern because of its tendency to form gels and fibres at neutral pH and moderate concentrations [35].
They occur so rarely that it is difficult to discern patterns or make reliable forecasts.
Part of the problem, they said, is that the sample of known terrorists and actual attacks is so small that it is difficult to establish patterns of suspicious behavior.
Palomares et al. (2014) state that it is difficult to use patterns without computational support to guide the software engineer.
It is difficult to propose patterns corresponding exactly to the method proposed by Mierswa [50], due to lack of information about their system.
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