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Given the large variation in recombination ratios across the catfish linkage groups, however, these determinations will be more difficult to make at present with the available genome resources.
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Very difficult to make up that loss at the distance.
Biomedical adhesives on offer are at present limited because it has been difficult to make water-resistant, non-toxic materials strong enough to hold together tissues.
But it will be difficult to make much progress on reconstruction if the insurgency continues at its present intensity.
At the moment it's difficult to make predictions".
At that stage it is difficult to make adjustments or consider alternatives.
"It's more difficult to make decisions".
But they are difficult to make.
Find it difficult to make a decision?
Eyes difficult to make out in newsprint.
Titanium parts are devilishly difficult to make.
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