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They have a very difficult challenge in getting developing countries on board, ironing out the big trade problems with Europe and getting the Congress to give the administration full negotiating authority.
They are difficult to perform, get funded, and get published.
Many skills are difficult to train and develop.
"Go back 10 or 15 years, and it was really only difficult to get land developed in California and New Jersey," he said.
There are too many tragedies because children develop eating disorders or psychosis or chronic depression, which is then very difficult to put right as they get older".
It's difficult to predict how it will develop.
It gets difficult to enjoy the view.
"There is increasing oil consumption, particularly in the developing nations, and oil is getting more difficult to find".
"But having it approved in dogs gives us a level of confidence regarding safety and efficacy in that species". Although scientists have tested different drugs in cats and dogs, Boothe and others say it has been difficult to get pharmaceutical companies interested in developing them.
He said that the N.I.M.H would need to see "a path to development" and suspects that "it would be very difficult to get a pharmaceutical company interested in developing this drug, since it cannot be patented".
As you move up the layers it gets much more difficult to develop and execute.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com