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From our study it appears difficult to further increase VPA doses in continuous administration, without incurring in undesired, serious side effects, at least when combined with dacarbazine and interferon- α.
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In addition, it was difficult to further degrade MB by increasing the irradiation time.
Although the core trainer physicians increased personal knowledge and self-efficacy skills in the training workshop they found it difficult to further disseminate information to their colleagues.
These authorities are facing difficult times as the gap between demand and healthcare resources is widening and the option to further increase county council taxes is not politically tempting.
In the second letter the formulation of action plans to further increase habit formation, and coping plans in order to deal with difficult situations they had encountered, were stimulated.
The influence of agrochemicals on important soil fungi is complex and difficult to predict, further increasing the difficulty involved in the management of soil fungal resources.
Also, as our students are already showing higher levels of deep relative to surface approaches to learning, it may be difficult to detect any further increase in deep approaches to learning [ 32].
Of note, the combined model with NT-proBNP and CCS without P-OPG already had an AUC of 0.84 and it is therefore difficult to increase the area further.
This lack of efficacy is probably due to the extended lifespan of dy W /mag mice, which makes it difficult to detect a significant further increase by anti-apoptosis treatment.
However further down each side may be more difficult to apply, and increase the danger of spillage on to the floor.
Even with contemporary computer power, as the complexity of the systems of interest increases, these two requirements become more and more difficult to fulfill, further pushing the need for custom codes and specialized hardware.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com