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Designed and highly optimized for performance, they are difficult to experiment with.
It's difficult to experiment with human subjects, and so to estimate toxicity scientists look to laboratory animals.
It's extremely difficult to experiment, to easily engage with startups, to find the best technology for a particular direction rather than the traditional way of doing things.
This makes it difficult to experiment with the medium, since each creation must be shared publicly for it to be viewed.
In Spain, for instance, labour law makes it "difficult to experiment", in the words of Martin Varsavsky, founder of FON, based in Madrid, which has knitted a global network of Wi-Fi base stations.
Until now, the problem has been that "it is simply too difficult to experiment and gain confidence in your own ability to design a space.
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"It is notoriously difficult to do experiments on mice that properly mimic Alzheimer's disease in humans," he said.
It is also notoriously difficult to design experiments in such a way so as to exclude the possibility of subliminal signalling and placebo effects.
We really need more people to do this as the nature of human donations means it is very difficult to plan experiments.
Ho and Zhang say the shortage of pure defensin material makes it difficult to conduct experiments that might tease out how it combats HIV.
It may be difficult to run experiments during a real-time flight travel both from practical points and also safety issues.
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