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However, effects of some other factors, especially medication, are difficult to examine, since the regular therapeutic process of patients should not be disturbed during urine collection.
TolA dependence was more difficult to examine, since delayed OM constriction in the absence of TolA leads to the non-specific accumulation of periplasmic proteins at cell division sites (Gerding et al., 2007).
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In the absence of randomized prospective studies, the effect of each covariate is difficult to examine independently since patients referred to a pre-dialysis clinic are probably less likely to require emergent dialysis initiation due to more regular follow-up.
These studies have to be performed first using animal models that mimic human breast cancer, since it is difficult to examine interactions between in utero exposures and breast cancer that is detected several decades later in women.
Unfortunately they are hung so far above eye level it is difficult to examine them closely.
Cotransmission is difficult to examine experimentally but can be explored using a computational model.
Pidgeon said it was difficult to examine the reasons for people's attitudes in quantitative surveys such as this.
"However, it's a little more difficult to examine this in humans, simply because they live so long!
While, it would be difficult to examine whether drinking itself was a causal phenotype that derived selection pressure.
It's sometimes difficult to find a balance between covering ground that's too broad, or selecting something too niche and difficult to examine.
The rectum is particularly difficult to examine.
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