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Collections housed in geographically isolated regions, such as the Hawaiian Islands, can be difficult to examine by scientists in other parts of the world.
Thirty-five metabolites appeared in 14 different metabolic profiles (males and females from the 7 experiments listed in Figure 1), making the data difficult to examine by direct inspection.
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Assessing biodiversity in the microbial world has always been a difficult problem: not only are microorganisms inherently more difficult to examine and differentiate by classical methods, but it is also not clear if the theoretical taxonomic frameworks, applied to more familiar life forms, even apply to the diversity of microbial life.
It is therefore difficult to examine incontinent patients by PET/CT imaging, even with the use of appropriate protective pads, which also become heavily contaminated, raising radioactive waste disposal problems.
As the diagnosis of cancer relies on the WHO classifications of diseases (ICD), which are regularly updated, it is difficult to examine time trends in cancer incidence by site covering different revisions of the ICD.
The internal geometry of volcaniclastic fans produced by aggradation during lahar events is difficult to examine in modern settings because of the frequent lack of three-dimensional exposures.
However, this hypothesis has proved difficult to examine directly because atomic movements in complex biomolecules cannot be visualized in 3D by using current experimental methods.
Unfortunately they are hung so far above eye level it is difficult to examine them closely.
Cotransmission is difficult to examine experimentally but can be explored using a computational model.
Pidgeon said it was difficult to examine the reasons for people's attitudes in quantitative surveys such as this.
"However, it's a little more difficult to examine this in humans, simply because they live so long!
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