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It is difficult to estimate well performance because a large number of parameters are used for characterization of a fracture network.
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Nevertheless, it remains difficult to estimate how well preventive measures work.
In addition, it is very difficult to estimate how well a participant has understood the information received [ 11].
However, the unpredictable location and geometry of the karst cracks and caverns makes it very difficult to estimate groundwater storage and movement, as well as contaminant transport.
10 14 The societal costs are difficult to estimate but the financial burden is well over $1 M per life affected.
It is very difficult to estimate the thickness of the degraded surface layer as well as the transparency of its interface with the bulk.
It is well known that mixture models are difficult to estimate and that, for example, multimodal likelihood and label switching problems can occur (Richardson and Green 1997).
The amounts of fossil fuels that can be recovered economically are difficult to estimate, largely because of changing rates of consumption and future value as well as technological developments.
Overall, it is exceedingly difficult to estimate the true burden, distribution and characteristics of STIs in Guinea-Bissau, as well as in many other countries in West Africa.
The diversity of unconventional oil and gas resources, their location and the technologies required to exploit them, make it difficult to estimate how the cost of recovering unconventional oil and gas differs from traditional wells.
Although allele frequencies can be well estimated from intraspecific data, small fitness differences have a large evolutionary impact but can be difficult to estimate with only intraspecific data.
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