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This happens because the population at risk of critical illness is particularly difficult to estimate, once intensive care units (ICUs) receive patients from many sources.
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As the strains were mainly isolated from only the western part of the world, it was difficult to estimate that those core genes would also represent the larger number of species, once they became available.
However, in the current study, 91% of children were on once-a-day dosing prior at prescreening, and it is therefore difficult to estimate the effects of this factor on the current across-dose comparison.
The long-term risks are enormous and difficult to estimate.
However, surface roughness is difficult to estimate in unstructured environments.
The first two are not too difficult to estimate.
*Civilian casualties are a touchy subject, notoriously difficult to estimate.
With earthquakes it is difficult to estimate initial losses so it was forced to revise its estimates during the year.
The size of the crowd was difficult to estimate.
Overall, as John Hawksworth of PriceWaterhouseCoopers says, it is extremely difficult to estimate the economic benefits.
That's what makes it so difficult to estimate what the timeframe will be..
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