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Due to limited data it is difficult to establish accurately radiological presentation and clinical outcome of these patients.
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Because prior knowledge on the expression conservation for human-mouse orthologs is limited (expression conservation may not be associated with sequence conservation [5], [12], [13], [14], [15]), it is difficult to establish a benchmark for accurately evaluating the computational methods used for assessing expression conservation in terms of sensitivity and specificity.
In view of multiple hindrances encountered in accurately identifying these organisms it becomes difficult to establish a good co-relation between their pathogenic potential and disease manifestation [ 44].
A novel approach using Monte Carlo methods has been developed, validated and used to model the response function of the counters and determine more accurately their effective centres, which have always been difficult to establish experimentally.
It is generally difficult to establish a coordinate system in which the cortical surfaces of different volumes can be accurately matched to provide consistent measurements [ 38].
Causality is always difficult to establish.
A formal mechanism proved difficult to establish.
Trends over time were difficult to establish.
That has made it difficult to establish a national figure.
It is difficult to explain this discrepancy, and it is difficult to prove accurately what caused the chylous ascites.
Accordingly, it has been difficult to accurately establish a relationship between fluctuating pressures on the surface of a cooling tower to inflow conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com