These results imply that not all mutations necessarily lead to EIAKI and that the possible genotype-phenotype correlation is complex and difficult to determine at the present time.
Unfortunately, the epigenetic changes of the entire Axin gene are currently unclear, and thus, the methylation statuses in the regions beyond the promoter and the first and second introns of the Axin gene, as well as their functional significance, are difficult to determine at the present time.
Recent international trends suggest that there is an increase in the incidence of CD. 2 Whether this finding represents a true rise in the incidence of the disease or merely reflects an improvement in diagnostic and reporting methods is difficult to determine at the present time.
As to the present case, whether AOSD was a part of PNSs or a coincidental disease was difficult to determine at first.
But, he maintained, it is difficult to determine at what interest rate loans become unfair.
The motives of the terrorists are difficult to determine at this stage.
Permissible assessment boundaries may therefore be difficult to determine at protocol writing stage.
It is rather difficult to determine what components present in plant extracts contribute to inhibit corrosion [27].
Actual fracture rates are difficult to determine based on the present results.
At present, it is difficult to determine whether the genetic effects presented in these studies could result from genetic factors mapping just outside the MHC region like the belr1 locus.
