The kernel images, however, are difficult to design for a large number of stored patterns.
Arguably, these can be more difficult to design for the optimal detection of changes with an acceptable false alarm rate, and they can be difficult to explain to managers, clinicians and non-statisticians.
Studies focusing specifically on pregnant women are difficult to design because of limited use of antenatal services in most vaccinated populations, especially during the early stages of pregnancy.
Studies on the toxic effects of muscle relaxants are difficult to design because of the need for mechanical ventilation and, consequently, concomitant administration of anaesthetic drugs which may influence the results.
Although more flexible and scalable, peer-to-peer minimum variance estimators are difficult to design because of message losses and lack of network coordination.
Also, these systems are often difficult to design because of the "top down" approach used: the designer generally knows how each component has to respond separately, but a centralized management system focuses his attention solely on the overall reaction of the system.
In a case of machining such complex surfaces it is difficult to design constant values of this process for the whole of the machining time and additionally ensure high production efficiency.
Its special characteristics have made it difficult to design instruments capable of performing a non-invasive evaluation of its structure and function in humans.
The radio resource allocation and packet scheduling schemes allows to get energy efficiency while keeping a certain level of QoS; however, it is difficult to design this kind of schemes simultaneously satisfying the QoS provisioning for both human and MTC users.
But whether or not they were difficult to design, a slew of PlayStation 2 games that industry watchers say may be some of the best ever made for any console are scheduled for release late this year, just when the game console war is expected to be at its most combative.
