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The extent of prescription opioid abuse has led to the development of formulations that are difficult to crush.
Experts believe the rise in heroin use may be linked to recently introduced restrictions that require manufacturers to produce tamper-resistant pills that are difficult to crush, and therefore, harder to abuse.
The mechanical strength makes the obtained geopolymers difficult to crush upon accidental chewing, and the geopolymers are therefore a safe and attractive material for controlled release of drugs with narrow therapeutic window, such as highly potent opioids.
Only that part of the shell around the hinge region remained hard and difficult to crush.
Patients who were admitted at the onset of acute obstructive suppurative cholangitis accounted for 73.5%% of the EST + EPLBD group and 69.4 % of the EST group.> The cause of stone removal failure in all four unsuccessful EST group patients was the presence of large stacked stones, which resulted in insufficient ML dilation making it difficult to crush the stones.
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For example, they have an extremely strong cuticle (skin) that is difficult for predators to crush -- and for insect collectors push a pin through.
On average, the bold snails had larger, rounder shells with wider holes characteristics that make the shell stronger and more difficult for predators to crush.
If the monks' demonstrations continue, analysts said, the military junta will face a difficult decision over whether to crush them by force and risk a still greater public backlash.
The scene at the Mashakalay crossing suggests how difficult it could be for American forces to crush the Taliban and Al Qaeda without striking across the border.
"He had to crush it".
He chose to crush me".
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