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The concentration of drugs required to achieve bactericidal activity may be several orders of magnitude higher than the sensitivity for planktonic bacteria, since it is very difficult to completely sterilize infected surfaces.
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It is impossible to completely sterilize tissue without compromising its function and integrity.
But it's impossible to completely sterilize spacecraft, largely because humans carry so many bacteria around with them: bacterial cells in our bodies greatly outnumber our own.
The only way to completely sterilize piercing utensils is by using an autoclave.
This is one way to completely sterilize the needle by killing all the microorganisms.
However, it is very difficult to completely analyze system requirements.
That's why it's difficult to completely eradicate them.
It is difficult to completely convert the initial phase into the final hierarchical zeolite.
However, owing to task complexity, it is difficult to completely eliminate the mistakes.
Thus, it is difficult to completely understand the mechanism of the eruptions in Unzen volcano.
Architecture transcends scales -- which makes it difficult to completely comprehend.
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