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In addition, the spike-in external control, such as C. elegans miR-39-3p, is also a popular normalization control, but it is difficult to completely regulate the amount of this artificial external control added to different samples.
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These days, with the Internet, it's even more difficult to completely erase someone's identity.
However, it is very difficult to completely analyze system requirements.
However, owing to task complexity, it is difficult to completely eliminate the mistakes.
Thus, it is difficult to completely understand the mechanism of the eruptions in Unzen volcano.
It is difficult to completely convert the initial phase into the final hierarchical zeolite.
Medication confounds are difficult to completely eliminate or adequately control for statistically.
Extended periods of immobilization of joints lead to contractures difficult to completely reverse by rehabilitation treatments.
These substances are coming from a variety of sources and are difficult to completely remove.
We confirmed that it is difficult to completely mimic the intestinal environment in in vitro experiments.
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