Docking study shows that few amino acids of active site of enzyme are also involved in meropenem binding, hence substrate is difficult to bind on active site properly and does not get hydrolysed.
The deal employs some mechanisms to create inertia behind the cuts — in particular, caps on discretionary spending — but fundamentally it is very difficult to bind the actions of a future Congress.
The resolution attainable on biomolecules is lower because they are often deformed or damaged at such high tip forces and because it is generally difficult to bind them to a surface sufficiently rigidly to withstand high scan forces.
Attempts have been made to improve devices using anti-adhesive or antimicrobial coatings; however, it is often difficult to bind coatings stably to catheter materials, and the low amounts of drug in thin-film coatings limit effective long-term release.
In MANET, attackers can forge the IP and hardware addresses easily, so a malicious node impersonates many identities and it is difficult to bind a single identity with one node.
Finally, purification of TFs is notoriously difficult, as they tend to bind to genomic DNA.
Interestingly, the shorter V2 loop of the "late" virus (Fig. 5C, shown in green) appears to occlude access to the CD4bs (shown in red), which would make it difficult for anti-CD4bs nmAbs to bind to their cognate epitopes.
It would be difficult for a single Rab6A molecule to bind to both the KIF1C motor domain and to KIF1C's C-terminus, as both binding sites involve interaction with the Rab6A 'switch domains' that report the identity of the bound guanine nucleotide on the Rab protein surface.
Combining these experimental results with a computational model confirmed the findings of previous laboratory studies: that Four-jointed makes it easier for Fat to bind to Dachsous, and makes it more difficult for Dachsous to bind to Fat.
High degree of chemical inertness inherent in zirconia makes it very difficult to covalently bind a suitable organic ligand to its surface.
