Sentence examples for difficult to be targeted from inspiring English sources

In this argument, gene B could be replaced by a function gained by resistance that is difficult to be targeted directly, such as transporter MRP1 in the case of cancer, or any other cellular function that distinguishes the target cells from "normal" cells.

Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted.

This smear will cause the target more difficult to be detected and even buried in clutter.

Moreover, recent in vitro and in vivo studies suggest that higher aminoglycosides exposure should be targeted for difficult to treat pathogens [23, 24].

However they caution it's difficult to definitively determine how ads are being targeted because the process is so complex and opaque.

Patterns by which specific CTD-protein interactions are disrupted by changes in CTD structure, as well as how downstream metabolic pathways are impacted, are difficult to target for direct experimental analyses.

While C. reinhardtii offers many advantages as an experimental organism, it is still difficult to obtain targeted knock-out mutants of a desired gene.

Yet information about how the N.S.A. has been using is new data-mining tools — a difficult target, to be sure — is in short supply.

Triple-negative breast cancers (TNBC) lack HER2, ER, and PR, so they are difficult to target and no molecular targeted therapies exist for these breast cancers.

Dendritic segments are not valid targets because they are difficult to target in the ablation phase of the experiments and their cell bodies are detectable in adjacent focal planes.

However, PPIs have been historically considered to be difficult targets for small molecular inhibitors due to the lack of suitable binding pockets to accommodate drug-like molecules.