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These problems are difficult to be overcome.
These factors are clearly identified in Portugal, in particular, due to cultural characteristics, because the fear of failure that typically an entrepreneur has to pass is a strong barrier difficult to be overcome.
This phenomenon suggests that the immunosuppressive state of the tumor microenvironment is more potent and complicated than that in peripheral blood and, therefore, much more difficult to be overcome.
Heys et al. [ 49] observed a stronger effect of the trunk length than the leg length on cognition, suggesting that early childhood growth might be less important than later childhood development, or its effect on adult cognition more difficult to be overcome.
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This is difficult and needs to be overcome by trial assays.
Some of the drawbacks of this approach which are difficult to overcome are also outlined.
Some obstacles that are typically more difficult to overcome are young children and existing pets, especially dogs.
One problem marketers find difficult to overcome is how do you get buyers to choose your product when they are in the habit of buying other brands?
When I was growing up, I suffered all types of abuse, but I find the most difficult to overcome was the abandonment and neglect.
What is difficult to overcome though are all the costs outside of production.
The danger is that Apple's current lead in high-end devices will be difficult to overcome because it is self-reinforcing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com