In summary, we provided an efficient approach for improving the carboxylation activity of Rubisco, one of the most abundant proteins on earth and also probably the most difficult one to be engineered.
Complex phenotypes, such as strain tolerance to toxic compounds, are difficult to be rationally engineered due to the limited knowledge about molecular mechanism.
Instead, the synthetic horns should be engineered to be (i) difficult to distinguish from wild horns but (ii) undesirable or unappealing in some respect so that buyers would place little value on them.
The misquotation would have been more difficult to engineer had there been an apostrophe after 'homosexuals.' I am convinced that in this instance the A.P. has been (unwittingly, I am sure) the flagellum Dei to recall me from my populist, illiterate wandering.
But the city is so solid, it would be difficult to re-engineer it".
The anaerobic spore-forming, gram-positive, solventogenic clostridia are notorious for being difficult to genetically engineer.
Their innovations were exceedingly difficult to reverse-engineer and thus were successfully guarded as trade secrets.
By this stage, Holden's 24 year old six-cylinder was thoroughly outmoded and would have been difficult to re-engineer to comply with pending emission standards and the introduction of unleaded fuel.
Moreover, it is difficult to engineer such materials when the skills being taught can be applied in varied ways and there many different routes to solving problems.
