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Our results unequivocally demonstrate that LRRK2 transgenic mice develop motor impairment consisting of small anomalies in rotarod performance (presumably reflecting a deficit in motor coordination and dystonia) and a strong deficiency in the hanging-wire test (reflecting muscle weakness), rather than hypokinesia which was difficult to be demonstrated in the actimeter.
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The condition of Theorem 3.1 is more difficult to be satisfied, which is demonstrated by the following example.
The mildest form of hepatic encephalopathy is difficult to detect clinically, but may be demonstrated on neuropsychological testing.
Most agreed or strongly agreed that broader downstream indicators of impact were important (Fig. 1, Question 4) but could be difficult to demonstrate and were not in the control of the researcher.
One idea in the book that struck me as unproblematic but proved surprisingly difficult to demonstrate is the notion that recorded music has played a decisive role in a levelling — incomplete, certainly, but a levelling nonetheless — of musical hierarchies.
A potential paraneoplastic link between malignancies and glomerulonephropathies is difficult to demonstrate, but is supported in our patient by the parallel improvement and longterm resolution of the two conditions under treatment.
However, the benefit of aggressive glycemic control with insulin on morbidity/mortality has been difficult to demonstrate and may be offset by side effects, especially hypoglycemia.
While it is difficult to demonstrate that masculinity is a "better" cue of aggression than of health, there are reasons to treat this as plausible.
Despite continuity with the major part of the rhabdosphincter, the compressor urethra is difficult to demonstrate because it is restricted to a relatively thin frontal plane) and because well-developed examples were very small in number [ 49].
"Hard evidence for effects in humans is difficult to demonstrate, though there are some exceptions," he said.
"There's nothing wrong with fishmeal it was just difficult to demonstrate that it wasn't one of the meat or bonemeals you were looking for". .
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