As PP1α is already nucleoplasmic, it is difficult to assess whether over-expressed taperin recruited additional PP1α to its localization site (Fig. 5B).
Thus, in population-based studies it is, in general, difficult to assess changes over time.
Pathologists active at the time ascribed this to artefact due to the introduction of colposcopy, leading to more frequent use of punch biopsies that were difficult to assess, and produced more "over-diagnosis" of lesions that would regress.
Second, women could have mammograms within or outside the programme (including after the last age for screening and differential screening practice between groups), so it is difficult to assess the excess over such a long period.
These are difficult to assess and need to be assessed over a period of time, and may or may not be large.
And yet the uncertainty about quarterback Alex Smith's broken leg makes it difficult to assess the Redskins' needs over the next few months.
Strict compliance to a GFD is associated with mucosal histology restoration and improved nutritional status in people with CD but adherence is difficult to assess accurately and has been frequently over-looked in studies [ 7, 11, 14, 15].
UN System fellows, on the other hand, return to different organisations and the impact of their learning on their home institutions is infinitely more difficult to assess due to limited control over their deployment and support once the fellowship is completed.
If MRSA isolations from surface cultures and urine samples (whose clinical significance can be difficult to assess in some individuals) are excluded, over the same period there were 1464 FCIs.
The value of this trade is difficult to assess, but appears to have increased over the past five years.
