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For humans, it is not that difficult to override our internal clock: staying up late or having an irregular sleep/wake schedule can influence our internal clock and make it difficult to arise when we need to.
First, if the environment was in favor of DNA (i.e., unfavorable to RNA – in regard of working as the chromosome) at the very beginning, the RNA-based system would have been difficult to arise.
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He added that he was extremely nervous and that he expects more difficult situations to arise.
The most difficult problems continued to arise in relation to foreign affairs and, above all, to Ireland.
The origins of the large apparent discrepancy in device J V characteristics become difficult to understand, arising from differences in built-in potentials and in the extraction layers' conductivities that can affect collection of stray current outside of device area.
Geologist L. Paul Knauth of Arizona State University in Tempe adds that Earth's early oceans were up to twice as salty as they are today--making it even more difficult for viable cells to arise.
In cases in which new technical systems impact the performance of distributed or co-located work teams or collaborative organisations, the resultant problems can be difficult to predict, often tending to arise under extraordinary and/or stressful situations.
We can expect that conflicts are even more likely to arise in situations where difficult medical decisions have to be made, such as critical medical situations in hospital.
A more difficult to detect problem arises when the original model is identified under the null hypothesis and the extended model is identified under the alternative but the information matrix of the extended model is singular under the null.
More fundamentally, the projection of the 3D object surface onto the 2D image means that valuable information about the object is discarded, which makes it more difficult to analyse distortions arising from the striking of the coin in the die and also of subsequent wear and corrosion [5].
It is often difficult to distinguish complications arising from the use of GDT from those of PAC insertion.
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