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BUT it's difficult to affect the long haul if you find yourself voted out of office.
Therefore, it can be difficult to affect the level of LDL-cholesterol in mice and to extrapolate data on lipid profiles from mice to humans.
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Nonetheless, the important motivators across setups in this study were mostly intrinsic and socio-cultural, which are difficult to affect while the demotivators were largely organizational.
Indeed, as shown before, the walker A mutations in either subunit appears to effect activity of both subunits, bringing down the total activity to near background levels, further arguing that it is very difficult to affect one ATPase without affecting the other in ABC ATPases.
But the group has long found it difficult to affect positive change in such matters.
And those abilities are more difficult to affect by other-directed regulation.
Such perceptions can be deep-rooted and thus difficult to affect change on an individual level.
In the recent words of James Comey, the FBI director, "the 50-state voting system is so dispersed and 'clunky' it would be difficult for hackers to affect the outcome". No computer-based voting machines are attached to the Internet.
You would find it more difficult, as a result, to affect the regulations".
"It's very difficult for an outsider to affect the course of the fundamental operations at G.M".
Without understanding what "being agile" means -- and embracing how the philosophy can be applied -- it's difficult to know how to affect the necessary changes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com