Evaluation is generally carried out by giving patients printed questionnaires, which have proven difficult to administer in daily clinical practice.
There are other problems too: it's difficult to administer in combination with other drugs and the infant formulation requires a cold chain.
State laws make it difficult to administer simple treatments in the home.
Demand-driven programs have many advantages, but can be difficult to administer and may face challenges in reaching the poor.
Also, it is difficult to administer intravenously because of its low solubility in aqueous media.
Difficult to administer, it has been applied with only limited success in India and Sri Lanka.
Usually in the elderly it is difficult to administer the same chemotherapy administered to younger patients because elderly patients tolerate chemotherapy poorly.
These combinatorial therapies are difficult to administer for both patient and caregiver and often result in tolerability issues.
Current treatments are limited, difficult to administer and often toxic causing long term injury or death in many patients.
A major challenge in doing so is that asset-building programs are difficult to administer.
