Sentence examples for difficult to accrue from inspiring English sources

Additionally, it has been difficult to accrue sufficient patient numbers for identification and validation of genetic risk modifiers with relatively modest effect sizes.

Thus, most studies with modest to large subject populations with advanced, metastatic BCC will be difficult to accrue.

Hence, despite very large sample numbers, it may be still difficult to accrue large enough sample populations for statistical comparison of Ep-CAM-negative with positive tumours.

As prospective randomised studies have proved difficult to accrue to, current recommendations are based on the reports of large series of prospectively collected data.

That POI is a rarer condition than polycystic ovary syndrome or endometriosis makes it difficult to accrue the requisite sample size possible in studying those disorders (Uno et al., 2010; Chen et al., 2011a; Shi et al., 2012).

It is difficult to accrue to randomized trials involving aggressive surgery, because patients often cannot comprehend that a "flip of the coin" could determine whether or not they undergo prolonged surgery with the associated risk of complications and death or perhaps go untreated for an imminently terminal condition.

These are difficult to fund, and it is hard to accrue adequate numbers of appropriate, eligible patients.

It's hard to accrue enough time.

The financial requirements for buying in Manhattan deter many young professionals from purchasing, making it even more difficult for them to accrue the needed assets for future homeownership.

Department officials said the changes will fix a two-decade-old technicality that made it difficult for airline crews and pilots to accrue medical leave, thanks to their unique hours and scheduling.

According to the report, "The policies that enabled an outrageously large portion of the world's wealth to accrue to the very top of the income spectrum have delivered a difficult present and uncertain future to a huge majority of today's youth".