This result adds a wrinkle to the already-difficult screening and treatment decisions faced by individuals who know they carry BRCA mutations and are likely to get breast cancer.
Thus, obtaining an exact estimate for the number of F1 animals to be screened is difficult, and screens are generally considered near saturation when multiple alleles of a given gene have been identified.
Depending on the size and appearance of the cleft, diagnosis of schizencephaly may be difficult during screening ultrasound and, when visualised, may not be confidently differentiated from HPE or porencephaly (intracerebral cavitation secondary to haemorrhage and ischaemia) [17].
This microfluidic chip could overcome some defects existing in the current preparation method such as low efficiency, wide distribution of diameters, as well as difficult for screening and collection.
However, the UW-WB is expensive and technically difficult for screening and clinical trials [ 1, 8].
These data suggest that it had been difficult during screening to position the legs correctly for children with deformity.
Indeed, although NDM producers have often high level resistance to carbapenems, several isolates that exhibited MICs comprised between 0.5 and 1 μg/mL, making their detection difficult on screening media containing high concentration of carbapenems [ 78, 93, 101].
Although detection of vascular CRP deposit in vivo appears to be difficult, cardiovascular screening programs are needed to identify and treat at least patients with high concentrations of serum CRP.
It makes it difficult to screen our clients or to practise safer sex.
Some of the characteristics of the disease itself can also make it difficult to screen.
