It is difficult to understand the ramifications, as the median time of drug delivery was just 3 days, limiting both beneficial effects and harmful ones.
Some still find it difficult to acknowledge the wider ramifications of one country setting aside international law to take upon itself the role of judge, jury and executioner.
Since the conditions under which the requirement will be deemed satisfied will be spelled out in an escrow agreement drawn up at the closing, Mr. Hall said, and since it is difficult to anticipate all the ramifications on such short notice, closing in escrow generally increases the risk of problems rather than eliminating them.
To give up one of these beliefs is difficult and often has many ramifications for one's other beliefs.
Prolonged litigation could have wider ramifications, making it more difficult for the Irish government to sell its 25 percent stake in Aer Lingus.
And guilty verdicts could have had other ramifications, like making it difficult for the executives to serve on corporate boards or to fulfill other functions that require a clean record.
There's also a growing concern in IT departments about how cloud virtualization affects the business of computer maintenance and repair, and it's difficult to say what the exact ramifications of that will be.
It is difficult to speculate on the biological ramifications of differential expression of each of these chemokines individually.
It is difficult to identify the human biological ramifications, if any, of this increasing PAH exposure.
The oil and shale gas drilling boom is reshaping the nation's energy map, and it is still difficult to predict the extent of its ramifications.
Like population ageing, the intensity of the globalisation process in the coming decades will be unprecedented and it is therefore extremely difficult to anticipate all the consequences and ramifications.
