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Many of the parents talk about the difficult progression to reconcile and befriend the enemy, and their own commitment is tested over and over again when they face hostility from their own people, or their own family members.
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Nevertheless, prophylactic total colectomy may be indicated if the frequency of CRC is high, and it is difficult to prevent progression to advanced cancer due to rapid development.
Prophylactic total colectomy should be considered in patients with a high frequency of CRC in whom it is difficult to prevent progression to advanced cancer due to rapid tumor development.
The layoffs are a difficult but inevitable progression of a bigger shift at the company as it has moved from being the world's biggest mobile phone maker into one that focuses primarily on networking technologies as well as developing and licensing IP related to that and its historical business.
It should be noted that it is difficult to monitor progression beyond one cell cycle in this assay since the iC2C12-FRG1 myoblasts rapidly lose synchronicity.
The complex nature of breast cancer makes progression difficult to predict and challenging to manage.
CKD is largely asymptomatic, making accurate identification and subsequent management of patients at risk of progression difficult.
Given this mixture of "early" and "late" vessels, it becomes difficult to follow progression of newly formed vessels as they evolve over time in tumors.
For instance, it is extremely difficult to judge progression if the peptide vaccine is administered as monotherapy and, in such cases, it is more appropriate to adopt OS or DFS as end-points.
Biopsy sampling error and variable timing of repeat biopsies make it difficult to establish exact progression times or distinguish true progression from persistence of undetected, early-stage occult carcinoma (Silverberg, 2000).
"Some of them want to progress their careers maybe out of Scotland and it is difficult to stop that progression.
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