Moreover, a serious problem is that some miRNAs are difficult to profile precisely due to their physical properties or post-transcriptional modifications, such as RNA editing.
These results contrast with those of Bruce et al. [41] who showed, in humans, that the recognition of an unfamiliar individual was the easiest with ¾ frontal views and the most difficult with profile views.
However, because MS-based proteomics tends to have data consistency (poor reproducibility and inter-sample agreement) [ 23] and coverage (inability to detect the entire proteome) [ 24] issues, it is difficult to profile all phosphorylation sites at whole time points.
However, it is difficult to profile mRNA and lncRNA transcriptome in early embryos because of the technical obstacles, such as the analysis of lncRNAs expressed at lower levels and in small amount of cell.
In human degenerative discs, it is difficult to profile these balances in vivo; however, the static compression model facilitates detailed longitudinal analysis of these balances in disc ECM metabolism during degeneration.
These regions are more difficult to profile and are more likely to be affected by repeats resulting in a higher background error rate plus less variability due to factors other than differential methylation.
He works as a private consultant and is sometimes called in by the mayor to help his former colleagues out with difficult high-profile cases.
Colleges have faced difficult, high-profile choices on free-speech matters, particularly following the August mayhem at the University of Virginia, where white nationalist Richard Spencer rallied torch-bearing followers.
She said: "It's vitally important that the CPS takes on difficult, high-profile cases where it believes there is a realistic chance of conviction and a public interest in going ahead.
