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Use of the vaccine has been limited because of inadequate supply due to the difficult production process, cost of production, a difficult administration schedule, and, probably most important, concern about side effects resulting from mouse brain material remaining in the vaccine.
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So when executives involved with Test Drive Unlimited, the ambitious online racing simulation due later this summer, start talking about the game, the first surprise is that they actually trumpet its long, difficult and expensive production process, which began in 2003 and has cost between $15 million and $25 million.
The heterogeneity in both the chemistry and structure of lignocellulose means that it is often difficult to optimise the production process in terms of pretreatment, enzymatic hydrolysis and fermentation to suit the various types of lignocellulosic biomass.
More difficult conditions of oil production process in recent years impose the necessity of finding out new technical solutions that will provide reliable and efficient lifting of reservoir fluid to the surface.
His ideas and designs were often far ahead of their time, and the idea of a fully automated production process was difficult for contemporaries to comprehend.
"The Matrix Reloaded" and "The Matrix Revolutions," released in May and November of 2003, respectively, earned more than a billion dollars worldwide, but the production process was notoriously difficult; the shooting alone took nearly three hundred days.
It was difficult to maintain high quality-controlled production process in a stable condition, especially for cell expansion of endothelial cells in vitro.
The weight loss in this region must be attributed to the evaporation of the impurity substance in gum rosin, such as turpentine, which was very difficult to remove in gum rosin production process [ 29].
"I worry every day about the homogenizing forces at work in my professional life," she said, adding that it can be difficult to preserve creativity within cable's production process.
He points out that even in the production process, these medications are more difficult to replicate than are traditional drugs, and that makes the entire process more costly.
Health and agriculture investigators say the bacteria may have emerged at any number of points in the production process, from the field to the supermarket, making it more difficult to pinpoint the source.
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