She emerges as driven and difficult, with a need for adoring courtiers.
Populism is on the rise, and the most difficult issues – the need for structural reforms, public debt, an overgenerous welfare system – are likely, once again, not to be discussed.
In the case of Neymar, a bedding-in season was only to be expected, made more difficult by the need for Barcelona to find their way in the post-Pep Guardiola era.
With more official material than ever online as well as free tutorials in how to solve difficult problems, the need for "spun" preparation material (which looks real but isn't created by the makers of the test) and tricks for solving weird SAT-specific problems is greatly lessened.
The increasing emergence of strains of C. albicans resistant to the commonly used antifungal agents has made clinical management of candidiasis increasingly difficult and the need for improved drug therapies crucial [2], [6].
Establishing change is always difficult, but the need for a clinically relevant, easy to apply case classification is beyond question.
(Tove) Living with diabetes is still difficult; given the need for intensive insulin treatment, frequent monitoring of blood sugar levels, and dietary concerns.
All these aforementioned factors make data interpretation difficult, reinforcing the need for meta-analytic studies in this area using homogeneous morphometric methodologies and including multiple samples of patients.
Fresh allografts stored at 4°C provide good clinical outcomes [ 14], but are logistically difficult given the need for donor-recipient size matching, testing for infectious diseases and implantation within a short time frame to ensure chondrocyte viability [ 15].
However, precise interpretation of such retrospective nonrandomized studies is difficult, highlighting the need for better and large prospective studies on the association between weight loss and survival in type 2 diabetes, especially in the elderly.
