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"We all knew it would be a difficult location, but we weren't prepared for how tough it was.
Perhaps the biggest advantage is that the boat and its gear could be built in a world-class shipyard, rather than in a difficult location like Mozambique.
This might seem a difficult location for an atheist to work in, but the reality was that, at Our Lady's high school in Mother-well, I worked within a warm, supportive community.
Endoscopic submucosal dissection (ESD) has been used successfully for the removal of esophageal or gastric SMTs; however, the EGJ has been regarded as a difficult location for ESD because of its narrow lumen and sharp angle.
"If the Intrepid, which is a great piece of New York, and I think an interesting place to visit, can draw three-quarters of a million visitors to a difficult location, I really feel strongly we can draw one million," he said.
This densely forested and difficult location was apparently one of the reasons that Machu Picchu was not raided of artifacts like other Inca sites when discovered by explorers.
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Why undertake such a difficult project? "Location, location, location," said Paul Slayton, a partner in Slayton Development Group of Garden City, N.Y., which is part of the venture.
Orsi et al. studied ultrasound-guided HIFU ablation of tumours in difficult locations, and reported no complications after ablation of 4 tumours located <1 cm from a major bile duct and 2 tumours located <1 cm from the gall bladder.
But already the opening of new tunnels, bridges, roads and rapid transit has led to an extensive rerouting of traffic that makes once difficult locations accessible.
But as the oil industry's technological advances succeed in unlocking oil from increasingly difficult locations, there is heady talk that California could be in store for a new oil boom.
One reason is the available access to difficult locations and hazardous areas in the plant, and another is the recent ratifications of standards designed with industrial automation requirements in mind.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com