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Further, they are not able to perform advanced analyses, such as bivariate diagnostic test meta-analyses, because they cannot maximize difficult likelihood functions, and they cannot be readily extended to include additional analytic options.
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Other simulation studies have shown that low levels of signal can make it difficult for likelihood methods to detect true positives (Wong et al., 2004).
Mr. Obama and his expanded Democratic majority on Capitol Hill now face the task of governing the country through a difficult period: the likelihood of a deep and prolonged recession, and two wars.
Mr. Bush's task in comforting the country is made more difficult by the likelihood that he will soon be calling on a nation that is already coping with the aftermath of Sept. 11 and a weak economy to be ready to send its troops into battle.
Our findings suggest that the mother's perception of an infant as fussy and difficult increases the likelihood of reporting depressive symptoms.
Any hit to one of these HMMs has a strong (though difficult to quantify) likelihood of marking a heterocycle-containing bacteriocin biosynthesis-like cluster, while two that are adjacent indicate an even stronger likelihood.
The aim of this paper was to show how the score statistic may be separated into the genetic and environmental parts, which is difficult with the likelihood criterion, and how it can be used to check parametric assumptions made on variance and correlation parameters.
Starting with something too difficult increases the likelihood of you quitting the program sooner.
It is difficult to predict the likelihood or scale of biological attack.
Astronomers found it difficult to establish the likelihood that all these events would have occurred, and the discovery of Charon provided information that further refuted the theory.
Making it all a bit more difficult will be the likelihood that Alan Greenspan, chairman of the Federal Reserve, will finally retire at the end of his term in two years.
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