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I was especially pleased about the level of civility and cooperation that prevailed--these were difficult issues to address.
"We've had a brilliant summer and won the Tour de France clean with a clean British rider but when there are more difficult issues to address let's confront them".
But there are still difficult issues to address.
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Q Are human rights a more difficult issue to address in a transparent way than other issues, such as energy efficiency or renewable energy?
When there is a difficult issue to address like mass killings, well-intentioned people and clergy will say the same thing: We can't understand why, but God's love will help us through it.
The study of mGlu heterodimers is a difficult issue to address due to two main points: the lack of specific ligands (especially for receptors from the same group) and the presence of both homodimers and heterodimers in cells co-expressing two mGlu receptors (Doumazane et al. 2011).
This is currently a difficult issue to address, as known variants are biased towards coding and promoter variants and no relevant datasets exist to train methods in the discrimination of true long-range enhancers.
This is a difficult issue to address [as recently shown by Acuna-Hidalgo and colleagues (56)] and would require very high sequencing coverage, perhaps even of multiple tissues, in all individuals and is thus beyond the scope of the present work.
Crossing the line from forcing difficult issues to be addressed to imposing solutions would doom the sustainability push to fail.
Negative comments and suggestions included 'how to initiate alcohol reduction apart from losing licence?; not sure how negative patients will be with the Interlock program; would like a full workshop on the intervention; still a difficult issue to effectively address'.
Authors' response: Even if we are more positive than Prof. Lane about the evidence supporting the elimination of mtDNA mutations over generations, we agree that it is a difficult issue to be addressed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com