Determining the phase of diastolic dysfunction for an individual patient remains difficult because of the interplay between relaxation and preload, which makes the routine pulsed wave Doppler indices useless – particularly in a setting where preloading conditions may change constantly and abruptly, as in many critically ill patients.
Despite their applicability, reliable structural models are difficult to construct due to the interplay between strong short-range order and long-range disorder.
For applications to industrial polymerization, kinetic control is particularly important and difficult to achieve due to the interplay between heat development and diffusional control occurring during polymerization.
Whether the extra or longer consultations are 'overutilization' or whether there was 'underutilization' in the past is difficult to establish, but the dynamic interplay between supply and demand is obvious.
But it's been difficult to study due to the complex interplay between genetic and environmental influences.
However, identification of the main causative factors is extremely difficult because these events involve a complicated interplay between the physiological condition of bivalves and environmental factors, so the cause of death can rarely be explained by a single factor.
Because of the complex interplay between these kinases, it is difficult to study their roles independently in animal models.
The only time when this has been done before was when Rex Harrison insisted on filming his solos live for My Fair Lady, because he said the intricate interplay between talking and singing made it difficult to lip-sync.
However, the bonding of phosphate to the metal oxide surface is difficult to unambiguously predict in detail due to the interplay between protonated surface species and hydrogen bonding.
Furthermore, the multiple intrinsic feedback pathways, the cross-organ communication, and the interplay between autophagy and carcinogenesis make it difficult to target a single pathway to treat metabolic diseases without triggering unwanted side effects.
