Interestingly, the most difficult instances for the latter three models appear to be those with the equal number of facilities and customers.
In colon cancer, we raise prediction accuracy in the most difficult instances from 87% to 93% for cancer versus non−cancer and from 83% to (astonishing) 92%, for with versus without liver metastasis, in well-established cross-platform evaluation schemes.
PMS5 [ 7] computes the common d-neighbors of three l-mers using integer programming formulation, which is an efficient algorithm for solving the difficult instances of PMS: (21, 8) and (23, 9).
That makes it difficult, for instance, for women who need maternity leave.
It is very difficult, for instance, for my team to make appointments with Alex, a young homeless woman with a criminal record and without a mobile phone, who suffers horrific hallucinations of abuse.
Using W4 (the smallest forbidden subgraph for monopolar graphs) as a cutting plane also helps little, solving one more instance, but might be useful for difficult instances with long running time.
Similar to highly heritable psychiatric phenotypes, the molecular elucidation of body weight regulation based on data from GWAS has proven more difficult than, for instance, for body height, inflammatory bowel disease or specific complex neurological disorders.
With respect to the understanding and meaning of biomarkers, reviews often point to gaps in knowledge, data and validation that render interpretation difficult; for instance background and baseline values are not available for many ubiquitous environmental chemicals and their metabolites [ 5, 31].
It is difficult, for instance, to get webbed feet to turn out.
It's very difficult, for instance, to find historic images of people of color.
