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This is expected for difficult inference tasks with low signal-to-noise ratio.
Variants located in intergenic or relatively large intronic regions were not analysed due to the difficult inference of functional significance.
The novelty of this work lies in using bifurcation tools to aid what turns out to be a very difficult inference problem.
However, since all these methods are based on the square transformation of the paired-measures difference variable, which makes exact inference about the resulting estimate difficult, inference is carried out using analytical approaches or methods based on Monte Carlo simulations.
The richness and stochastic nature of the model makes for a difficult inference problem, especially when using a small number of summary statistics calculated from the sequence alignments of each taxon pair.
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This is true, and it renders difficult inferences from what is said in the Republic to what Plato thinks.
There have been some prior methods to solve MP phylogenies optimally, as well as to solve more difficult inferences, such as the inference of phylogenetic networks incorporating both mutation and recombination [ 16- 18].
The analogous microarray experiment yields thousands of Wilcoxon statistics, one for each gene on the array, and confronts the statistician with a difficult simultaneous inference situation.
Although heuristics guided by local search problems, especially SPR and TBR, have been very effective for many intrinsically difficult phylogenetic inference problems, our experiments indicate that the tree space for RF supertrees is complex.
If this turns out to be difficult, the inference of a universal gene regulatory network for a broad range of cell types from just, say, expression data without detailed knowledge of actual TF binding in each cell type might be impossible.
Manual logs and medical device data are collected by patients, but these multiple sources of data are presented in disparate visualization designs to the clinician making temporal inference difficult.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com