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Nevertheless, risk factors for NIV failure should be known by ICU clinicians, hypoxemic ARF remaining the more difficult indication to manage with NIV.
It is another ethically difficult indication, as the possibility exists that there are no zero-mutation embryos for transfer but just embryos with a low mutation load (that is, the ratio of mutant to normal mtDNA) under a certain disease-specific threshold, meaning that the risk for an affected child is not eliminated but only reduced.
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However, the retrospective nature of this study makes confounding by indication difficult to control.
However, the retrospective nature of this study makes confounding by indication difficult to control and further studies regarding the timing, dosing, and method of administration are required.
Comparisons between studies are made even more difficult because treatment indications for latent TB vary considerably.
Previous studies have shown that bevacizumab is also effective in this difficult-to-treat indication (Zhu et al, 2006b; Sun et al, 2007; Siegel et al, 2008).
Some units were able to directly relate urinary catheter use to the Bladder Bundle indications whereas other units found it difficult to apply these indications to both their patient populations and the units existing context.
The government is growing increasingly defiant, an indication of difficult negotiations to come for the opposition.
It had been maddeningly difficult to get any indication of how Pat was doing outside of the occasional tongue lashings in practice.
The new names of the tablets made it difficult to remember the indication for the treatment.
This is important because senior consultation advice and pertinent clinical infectious signs are rarely recorded [ 15], making indication sometimes difficult to elucidate in the daily ICU note.
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