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Third, the study is based in a demographic surveillance site which provided a sampling frame and key demographic information on the target population, including a longstanding delineation of village boundaries that is often difficult for studies to establish.
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It is difficult for observational studies to account sufficiently for time-dependent variables.
Analysis of the effect of external hormones on colon cancer must take into account the lag time in cancer development, although it is difficult for observational studies to account sufficiently for time-dependence.
For several reasons, it would be difficult for epidemiologic studies to detect the NRC-estimated cancer risks in the United States.
As with human studies, however, it may be difficult for animal studies to distinguish those aspects of impulsivity that are predisposing for AUD phenotypes from those that develop concurrently with or as a result of the disorder.
However, we found that using models of this kind it was more difficult for case studies to link their work to broader societal issues such as human well-being, sustainable ecosystem management, governance, and competitiveness, than to their own concerns.
The heterogeneity of copy number alterations (CNA) observed in EOC has made it difficult for small studies to be able to accurately identify the true frequency of the less common CNAs or to reproducibly identify CNAs that correlate with clinical parameters.
It is inherently difficult for packaging studies to replicate "naturalistic" exposure to packaging as it occurs in real-life.
This is difficult for individual studies to overcome because birth defects are rare outcomes and prospective cohort studies may not be feasible to conduct.
In reality, it is difficult for single studies to accomplish large and fully balanced sample because of the limitation of resource, the large number of known and unknown confounders and their complex interaction.
For example, it may be difficult for study participants to make judgments about future use because it is hard to fully comprehend the implications of such decisions given the rapidly changing landscape of biomedical research in general, and genomic science in particular.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com