The design of parallel architectures in particular is a complex and difficult endeavour that makes modelling and simulation essential tools.
Building a community is a difficult endeavour even under perfect conditions, and changing the way a community works once it has been established is even more difficult.
It's a difficult endeavour to successfully pull off, though; considering how past attempts like Cowboys vs Aliens, Jonah Hex, and A Million Ways to Die in the West have fared.
This is why dealing with the effect of structural racism – a racism that has unleashed, and is continuing to unleash, its disintegrative effects on people and society – is such a difficult endeavour.
Confirmation theory has proven a rather difficult endeavour.
While nowadays a profound selection of sampling techniques, molecular topologies and theoretical approaches is available, the analysis of actual simulation data remains a difficult endeavour.
However, bringing cherry blossoms to the nation's capital proved to be a difficult endeavour.
The peninsula's defences had been greatly improved by Abu al-Hasan's construction of new walls, towers, magazines and a citadel, making its capture a much more difficult endeavour.
Attributing causation to putative pathogens has always been a difficult endeavour with the gold standard remaining fulfilment of Koch's postulates [36].
Trophic studies in host-parasite networks are scarce and traditional approaches applied to characterize parasite feeding preferences and host use have important drawbacks or are of difficult endeavour in natural conditions [4].
For complex diseases such as alcoholism, however, this is a very difficult endeavour.
