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"However, using these items requires the brain to make a more difficult discrimination – what we call pattern separation, which seems to be the process that is enhanced by caffeine in our case".
This latter effect varied with target discrimination difficulty, with an increased influence of the emotional distractors on subsequent target-related frontoparietal activation in the more difficult discrimination condition.
"However, using these items requires the brain to make a more difficult discrimination - what we call pattern separation, which seems to be the process that is enhanced by caffeine in our case". Only a few previous studies have been carried out into caffeine's effect on long-term memory, and those that have been done generally found little effect.
First, probes were more closely spaced around the standard in the temporal generalization task, and a narrower spacing of probes (i.e. a more difficult discrimination) has been proven to affect the decision stage of the timing process with a lower (i.e. more "strict") threshold in the most difficult discrimination [92], [93].
In contrast, compatible binding sites are more likely to lead to a difficult discrimination task.
Candidate cancer genes are thus prone to include false positives as a consequence of the difficult discrimination between passenger and driver mutations (6, 7).
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When primates and dolphins are given a "bailout" response allowing them to avoid making difficult discriminations, they have been shown to choose the bailout option in ways that are very similar to humans (Smith et al. 2003).
Points near 0% or 100%, where the base frequency and comparison frequency are very different, correspond to easy discriminations, whereas points near 50% correspond to difficult discriminations.
They suggest that tasks involving difficult discriminations but easy peripheral selections tend to invoke longer fixation durations, while tasks involving easy discrimination but difficult peripheral selection (due to either an abundance or similarity of distractors around a target) tend to have shorter fixation durations but evoke a greater number of saccades.
Following the training day, rats were tested on a series of increasingly difficult discriminations (Table 2).
In all patients CSF Aβ42 correlated significantly with the ability to make the difficult discriminations, but not easier discriminations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com