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This can be a difficult assumption when examining the interaction of effects as in our case with comorbidity.
This is the more difficult assumption to defend, and also that which is most important with regard to the novel ideas outlined in this paper.
Prediction performance will degrade when this assumption is not met, but it can be a difficult assumption to verify, particularly for disease phenotypes with heterogeneous etiology.
However, given the consensus among scientists that climate is changing, it is a difficult assumption to defend at longer time scales, such as a century, or the 50 80 year rotation length of managed, even-aged stands in the U.S. Northwest.
Similar(56)
For those on the left, the realisation that there may be more to be done than not being overtly racist can be surprisingly difficult; the assumption that we can rest on our laurels and focus on protesting against other people's prejudice extremely tempting.
Olson's thesis, which suggested that group mobilization to advance a common interest may be difficult, challenged the assumption of the pluralist school in political science, according to which individuals readily mobilize to defend the interests of the groups to which they belong.
Modeling of fracture clusters is difficult with the assumption of random fracture locations.
A substantial percentage of the missing data in these associations was related to this modified intention to treat approach, making any type of assumption difficult.
The absence of empirical long-term evidence makes this assumption difficult to validate, hence survival modelling methods were required to estimate long-term disease outcomes.
However, selecting an appropriate tool to fit a given context is difficult because the assumptions for the approaches greatly vary.
In general, finding examples which satisfy physical realizability conditions, it is difficult without any assumptions on P.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com