Sentence examples for difficult and significant from inspiring English sources

The pope said the synod "would consider concrete solutions to the many difficult and significant challenges facing families in our time".

It is pointed out that, in addition to their theoretical interest, hybrid systems have been allowing for tangible improvements in recognition performance over the standard HMMs in difficult and significant benchmark tasks.

The England team to play Brazil in Saturday's high-profile friendly may be missing several first-choice players through injury, but Kaká says the five-times World Cup winners face a difficult and significant challenge against a side he believes can win next summer's tournament in South Africa.

In a sermon Monday in Guayaquil, Ecuador, the pope said the bishops will "consider concrete solutions to the many difficult and significant challenges facing families in our time".

Conclusion: The parenting role of the father to his daughter may be one of the most difficult and significant of human relationships.

Our results and those of previous studies 2 9 raise difficult and significant questions about the ethics and pragmatics of end-of-life medical care and the intentions and scope of hospice care.

Cutting words into stone is a difficult, deliberate and significant business.

Content issues: I think the manuscript would benefit from a description of the other option of intubating a patient with a true difficult airway and significant pulmonary compromise: i.e. place a single lumen tube to improve oxygenation and ventilation, then exchange over an airway exchange catheter (Cook).

Our project demonstrates that while preventing falls in hospital is difficult and requires significant and sustained culture changes in the practice setting, volunteer companions can play a role in enhancing the care of older Australians during their hospital stay.

The only useful marker for diagnostic tools still is PrPSc [ 37, 38], but its application in an ante-mortem test of prion disease in animals and humans, as proposed by Castilla and collaborators [ 39, 40], with the "Protein Misfolding Cyclic Amplification", is still difficult and no significant results are available yet.

One PHC in the block was selected based on an assessment of difficult geographic terrain and significant presence of poor and marginalised communities, and the second one randomly.