Despite their small size, which makes surgery difficult and limits repetitive blood sampling, murine models have been widely used, not because they are more faithful to adult human pathophysiology than larger mammals but because they are inexpensive, easy to handle and care for, and with availability of gene knockout and overexpression strains.
Slow movement, or bradykinesia, can limit facial expressions, make the task of walking extremely difficult, and can make repetitive movements such as brushing teeth also hard.
Of course the reality of most robots is that they are designed to do all sorts of repetitive, difficult and dangerous tasks - including, perhaps most famously, the kind of bomb disposal shown in 2009's The Hurt Locker.
Both the vocal writing, with its ornate filigree and fractured phrases, and the orchestra music, with its intricate textures and repetitive figurations, are difficult to pull off.
The repetitive content returned for genomes sequenced by Illumina tends to underestimate the abundance of repetitive elements because small and repetitive reads are difficult to assemble within long repeat regions using this technology.
Sequencing and annotating mucin genes is notoriously difficult due to their large size and repetitive nature.
Telomeres are particularly complex and repetitive, and thus very difficult to assemble correctly.
Sex chromosomes therefore become a haven for deleterious mutations and repetitive elements that are difficult to purge.
Knowing how to deal with women who are upset can be difficult, and the work can be repetitive, so it's hard to be as bubbly at 4pm as you were at 9am.
This change in vascular anatomy can make repetitive TACE difficult and limits the long-term efficacy of TACE.
