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Albert has always been "difficult and exacting, scornful of convention".
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Records are rarely maintained from one rotation to the next, funding for long term monitoring is often a low priority, detection of small changes is difficult, and often the exact location of sample plots is poorly recorded (Evans, 1984).
In view of the multiple roles of MSCs in vivo and the influence of local microenvironment on MSCs, it seemed difficult and complicated to determine exact mechanisms underlying the protective effects of MSCs on pancreatic β cells in T2D rats.
This difficult demand inevitably exacted its own price.
But the Wrights' experiences demonstrate that doing cutting-edge work in a difficult and highly competitive field can exact hard personal choices from anyone.
As such, clarification of exact meaning is difficult and subjective.
It's the other types of queries that are difficult, and it's difficult to pinpoint an exact time when these changes began.
Since an analytical description of these complex spatial fluctuations is difficult, an exact modeling and analysis are not appealing.
It is difficult to describe the complete and exact neuropathological consequences of stress exposure in the human brain as stress can occur in so many different forms and depends on an individuals coping strategy and stress sensitivity.
Calculations aren't easy (fraction of a fraction of a fraction, remember), and exact measurement is also difficult.
Collect information: It can be very difficult to get exact numbers and data after a disaster, but having basic information available, like the populations of different towns and villages, can make it easier to make educated guesses about needs, as well as presenting the context in funding proposals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com