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Very high levels of mature tRNAs make detection of unprocessed primary transcripts difficult, and definitive conclusions about any biological relevance of these additional promoter sequences cannot be drawn.
However, because nausea and vomiting are likely to be under reported, measuring this well-recognized side effect is difficult and definitive conclusions from the observed results cannot be drawn for this variable.
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They turned to studies of families and of parents and children, but data analysis has been difficult and any definitive answer elusive.
The preoperative diagnosis of PRMC is difficult, and a definitive diagnosis can usually only be made based on the findings of histopathological examinations after surgery.
It is difficult to give a precise and definitive 'instruction manual' on how to find recruits, as inclusion/exclusion criteria to the study as well as the population being recruited will dictate the best methods.
From a clinical standpoint of view, it is difficult to obtain a clear and definitive diagnosis of pneumonia in the nursing homes population beacause of the multitude of comorbidities (e.g., heart failure, chronic obstructive pulmonary disease, pulmonary fibrosis) often altering the manifestation of the respiratory infection.
The efficiency of control programmes for Salmonella in pigs, reported among the EU Member States, varies and definitive eradication seems very difficult.
The diverse study designs and methodology across the reviewed publications restricted the cross-applicability of findings and makes definitive generalisations difficult, and the diversity of resilience measures and outcomes precluded meta-analysis for the quantitative studies.
Also, our study was a retrospective review, and it is difficult to draw definitive conclusions about the disease process.
The scenario depicted by these cognitive models is quite complex and it is difficult to find definitive evidence in favor of one of them.
Cross-sectional methodologies make it difficult to draw definitive conclusions about the history and progression of anxiety and depression over the cancer journey in this population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com