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Why should a man of proven ineptitude in foreign affairs who is leaving an eight-year legacy of decline — in our security, our economy and our stature in the world — be expected to help guide others in resolving so complex and difficult an issue?
Although various in vitro DNA replication systems have been established [ 53– 56], dissecting-out the precise mechanistic roles of the various component proteins is difficult, an issue compounded by the fact that many replication factors are ATPases that are difficult to individually inactivate using available nonspecific ATPase inhibitors.
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Information management and system architecture in these can stand for a difficult issue even with a single teleoperated robot.
Measurements of contact angle on the surface of a gel is a difficult issue.
However, the design of a controller is still a difficult issue because of the material flexibility.
"The Twitter thing is a difficult issue and there's a line to tread.
For an Ombudsman scheme, this is a difficult issue.
I'd say that's a bit more than just a "difficult issue".
Farage said it was a "difficult" issue and that it was not a manifesto pledge.
"It's a difficult issue".
"That's a difficult issue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com