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Thomas said it was "about as difficult a loss that I've had in coaching since I've been here".
But even in Dolan-land, with a multiyear contract extension he received before the bottom fell out last season, Thomas probably doesn't have that luxury, especially after 27 turnovers last night and what he would call "about as difficult a loss as I've had in coaching since I've been here".
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In this study, we combined analysis of gene expression and chromatin dynamics in a way that allowed us to attribute effects directly to the induction of Hairy, inferences that would be difficult with a loss-of-function assay due to kinetics of depletion and secondary effects.
With a crucial Game 4 against the Knicks coming up today and a difficult loss in Game 3 to digest, Bird figured a day of relaxation and contemplation in New York would serve his team well.
"It's a resilient tree," Mr. Calvanese said, sounding like a coach defending his players after a difficult loss.
"The range of emotions I feel are as far apart as possible after such a difficult loss at the US Open [Mickelson recorded a record sixth runner-up spot in the US Open behind Justin Rose last month].
He was 79. "It was just a close family; it's been a difficult loss," the Engels' lawyer Steve Shaver said.
She added that although it was difficult to contemplate when a loss was fresh, her own experience indicated that it was wise to replace a pet as quickly as possible.
"It is difficult to quantify such a loss… Imagining how his life would have been different if he had studied for two years under Mr. Gilad, and earned his teacher's respect and support, requires more speculation than the law permits," the judge wrote.
Infection of cell cultures with cell-free virus isolated from HIV-infected patients is notoriously difficult and results in a loss of viral variation.
For this reason, group-level statistics for optical imaging are difficult and lead to a loss of statistical power when performed this way.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com