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One of the possible explanations for differing thresholds for the OKR and OMR is that the OMR is not mediated by the optokinetic system, but rather by other motion detection systems.
The pathway taken in this divergent response is linked to the treatment dose and hence amount of DNA damage achieved [ 9] however it is clear that differing tumour types have dramatically differing thresholds for the effective induction of apoptosis as opposed to proceeding with DNA repair.
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Constraining the sex effects (differing thresholds for males and females) to be equal over the six age groups deteriorated the model fit significantly as compared to the saturated model (model 2: χ(5) = 17.69, p = 0.003).
The differences may be explained by differing thresholds for reporting positive results.
A possible reason for the conflicting data arising from studies of AP antibodies in preeclamptic women is differing thresholds for a positive test for AP antibodies and a lack of standardization of the assays used in these investigations [ 5].
Alternatively, differing thresholds for surgery may exist between private and public patients.
This discrepancy could be due to weaker effect sizes for trans eQTLs in general compared to cis or due to differing thresholds for significance.
While this strong predictor presumably captures a measure of severity of headache and seriousness perceived by the patient, it is also probably strongly influenced by the local pre-hospital system and might not be transferrable to regions where people have differing thresholds for calling for an ambulance.
Differing thresholds might be adopted for commencement or cessation of treatment.
It was hypothesised that relative intensity difference thresholds (i.e. Weber fractions) for 16-Hz vibration mediated by the non-Pacinian I (NPI) channel would differ from relative intensity difference thresholds for 125-Hz vibration mediated by the Pacinian (P) channel.
Confusing guidelines that are difficult to follow or differ in thresholds for treatment which often change over time have previously been identified as barriers for implementing guideline recommendations.[ 10] In the Netherlands, this has lead to the development of a national multidisciplinary guideline for cardiovascular risk management that became available in 2006.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com